After their mother's death in a suspicious fire that burns down their house, Dean and Sam Winchester live a life on the road with their father as they grow up. Years pass and the boys team up to find their father, John, who went missing on a hunting trip. However, their father is not a typical hunter: he hunts supernatural creatures like ghosts, vampires, and various demons and he's trained his sons to do the same. Along the way, Sam and Dean save innocent people, fight creatures and ghosts, and collect clues to their father's whereabouts. Sam begins to mysteriously develop psychic abilities and visions as they travel. They eventually find their father, who reveals that the creature that killed Sam and Dean's mother years earlier is a yellow-eyed demon and the only thing that can kill him is a legendary gun created by Samuel Colt.
The season follows Sam and Dean as they deal with their father's death and continue to hunt the Yellow-Eyed Demon, who caused the fire that led to the deaths of their mother and later, Sam's girlfriend, Jessica. They have assistance from new allies Ellen, Jo, and Ash. Part of the Demon's master plan is eventually revealed as he gathers Sam and others like him, leading to Sam dying. Dean makes a deal with a crossroads demon to bring back Sam in exchange for his soul, which will be collected in one year. In a final confrontation, in which Dean kills the Yellow-Eyed Demon, a Hell's Gate is opened, releasing numerous demons from within.
The season mainly focuses on trying to save Dean from his deal and tracking down the demons that were released from the gate. Along the way, the brothers meet a demon named Ruby, who has an interest in Sam and claims to be able to help save Dean. Also, they meet Bela Talbot, an "acquirer" and seller of occult objects, who is constantly a thorn in their side. The brothers eventually learn what demon holds Dean's contract: a being of great power named Lilith. The brothers, along with Ruby, track her down and attempt to kill her. Lilith is unable to stop Sam due to his mysterious abilities; however, Dean's contract expires and his soul is taken to Hell.
Dean is rescued from Hell and brought back by an angel named Castiel, one of several angels who appears throughout the season. The rest of the season follows the brothers as they work with Castiel to stop Lilith's plan of breaking the 66 seals, which would allow Lucifer to walk free once again. Sam and Dean's relationship is also strained as Sam starts siding with Ruby over Dean. He also begins to give into his demonic side by drinking demon blood to become strong enough to defeat Lilith. After tracking down and killing Lilith, Sam learns her death is actually the last seal and Ruby was deceiving him all along. Dean arrives too late to stop him, but kills Ruby as Lucifer's prison opens up beneath them.
The fifth season revolves around the fight to stop Lucifer and save the world from the Apocalypse. Throughout the season, Dean and Sam battle both angels and demons as they fight their destiny to become the vessels of Michael and Lucifer. Unable to defeat Lucifer, they collect the rings of the Four Horsemen of the Apocalypse, which act as the keys to Lucifer's prison. The idea of destiny versus freedom and choice plays a large role. Throughout the season, Dean, Sam, Castiel, and Bobby each have a crisis as they near giving up. However, through each other's support, they continue forward until the end. Also in this series Castiel rebels against Heaven for Dean. It is also notable that Bobby and Castiel have an ongoing friendship during this season, while Dean and Sam grow further apart.
The sixth season begins a year after the end happenings of the fifth with Dean living a happy life with Lisa and Ben. Sam returns to the world of the living and teams up with Dean, who leaves his new life behind. Sam has been working under Samuel in order to hunt and capture alive Alpha monsters (first of the gene pool). Castiel is barely helpful anymore because the Heaven civil war has taken its toll. It is discovered that Samuel is following Crowley's orders in exchange for the return of his daughter. Crowley wants to use the Alphas to locate purgatory, in which there are a vast collection of souls that could be used for power. Castiel brought back Sam without his soul, and Dean implores the help of the Horseman Death in order to retrieve it. Death puts a wall up in Sam's mind so that he will not remember hell. The old Sam returns with no memory of the past year. It turns out Castiel made a deal with Crowley for each of them to receive half of the souls in purgatory. Dean doesn't like the idea and tries to stop the duo. To stop the Winchester brothers and Bobby, Castiel knocks down the mental barrier in Sam. Castiel betrays Crowley, Crowley becomes allies with Raphael and performs the ritual to open the doors of purgatory. It fails because they had fake dog's blood and Castiel appears full of power from having done the ritual himself. He obliterates Raphael and Crowley escapes. When the Winchesters try to talk Castiel into reason, he reveals that he is not an angel anymore: he has become God.
In season seven, the Winchesters will find themselves in an increasingly sinister, changing landscape, up against a new foe unlike anything they've ever fought. They'll find their old tricks, weapons and hiding places all rendered useless. All they'll have is each other. And the certainty that, like the last of the cowboy outlaws, whatever they face, they're not going down without a fight.
Season seven finds Dean and Sam reeling from the loss of their friend. Sam's violent memories of Hell threaten to overtake him, threatening not just his life, but his brother's as well. Meanwhile, Dean struggles under the weight of a secret that threatens to tear them apart. And even as the brothers traverse the backroads of America, hunting things that go bump in the night, something is coming for them. They are about to face an enemy more cunning and adaptable than any they've ever fought. As the landscape around them becomes increasingly treacherous, the tools they've come to rely upon will be stripped away. Our heroes, like so many outlaws before them, will find themselves utterly outmatched and outgunned, with no one to rely on but each other.
The thrilling and terrifying journey of the Winchester brothers continues as "Supernatural" enters its eighth season. Sam (Jared Padalecki) and Dean (Jensen Ackles) have spent their lives on the road, battling every kind of supernatural threat. Over the years, after dozens of bloody adventures, they have faced everything from the yellow-eyed demon that killed their mother to vampires, ghosts, shapeshifters, angels and fallen gods. They even came face to face with Lucifer and the Four Horsemen in averting the Apocalypse. With the help of allies – both human and supernatural – they've discovered that every threat they vanquish opens a new door for evil to enter in. In the show's seventh season, their hunt for the dreaded Leviathans – monstrous creatures escaped from Purgatory – has cost them dearly, claiming the life of their best friend and father-figure, Bobby Singer, and shattering their protector, the fallen angel Castiel. As dawn arrives after their endless struggle and sacrifice to defeat the world's evils, they know that, come nightfall, something otherworldly – something supernatural – will claw its way out of the shadows, demanding their attention. The series stars Jared Padalecki as Sam Winchester and Jensen Ackles as Dean Winchester. "Supernatural" is from Warner Bros. Television in association with Wonderland Sound and Vision, with executive producers McG (“Charlie's Angels,” “The O.C.”), Robert Singer (“Midnight Caller”), Jeremy Carver (“Being Human”), and Phil Sgriccia.